146 results found | searching for "viral"
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The global Cryo Electron Microscopy Market is witnessing robust growth, with the industry size valued at USD 1.40 billion in 2024 and projected to reach USD 3.40 billion by 2032. According to the latest industry analysis, the sector is expected to expand at a compound annual growth rate (CAGR) of 11.65% between 2025 and 2032, underscoring its increasing significance in life sciences, biotechnology, and pharmaceutical research. Cryo-electron microscopy (Cryo-EM) has emerged as a game-changing technology for imaging macromolecules at near-atomic resolution without the need for crystallization. This capability has positioned it as an indispensable tool for structural biologists and drug developers, particularly in tackling complex diseases such as cancer, Alzheimer’s, and viral infections. With pharmaceutical companies and research institutions striving for higher accuracy in molecular visualization, the demand for Cryo-EM technology continues to accelerate worldwide. Read MOre :https://www.snsinsider.com/reports/cryo-electron-microscopy-market-7338
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New Insights Into the Pathogenesis and Diagnosis of Rheumatoid Arthritis The hallmark of rheumatoid arthritis (RA) is erosive arthritis, an autoimmune disease that ultimately results in joint deformities and functional loss. It can also be complicated by pulmonary disease, cardiovascular disease, malignant tumors, and depression. The etiology of RA remains unclear. However, infections have been suggested as environmental triggers in as many as 20% of patients. Due to its perplexing etiology, a more detailed exploration of the pathogenesis of RA has been presented in an article titled "Altered antibody response to Epstein-Barr virus in patients with rheumatoid arthritis and healthy subjects predisposed to the disease" published in Immunol. The article delves deeper into the potential connection between Epstein-Barr virus (EBV) and RA, employing dependable tests that quantify antibodies directed against specific EBV antigens. So why did the research team link EBV to the development of RA? A disease similar to RA called polyarticular arthritis is induced by various viral infections, including rubella, HTLV-1, parvovirus B19, etc. Given that EBV has been connected with other autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, it is reasonable to assume that this virus may also be related to the pathogenesis of RA. Therefore, this article investigates the EBV antibody patterns in rheumatoid arthritis patients to assess the heritability of the antibody responses to the EBV-encoded EBNA1 protein, ultimately concluding that the levels of EBNA1 antibodies are notably dissimilar in RA patients compared to healthy individuals. Nevertheless, the findings reached in this article represent just a fraction of the complex investigation into the etiology of RA. Undoubtedly, the uncertain underlying causes of RA pose challenges for accurate diagnosis. RA can affect individuals of any age, but it is most frequently diagnosed in individuals between the ages of 35 and 50. Early diagnosis of RA can help identify people at risk of RA and prevent complications and disease progression. Modern imaging techniques, such as X-rays, magnetic resonance imaging, and ultrasound, aid in diagnosing RA by capturing images of affected joints. However, these methods are challenging for early RA diagnosis due to the similarity of early symptoms with those of other diseases. Additionally, detection methods that use serum markers, such as the anti-cyclic citrullinated peptide test in combination with rheumatoid factor, can improve the final diagnosis of patients with negative results from routine tests. As an efficient and precise method, IVD immunological assays and test kits rely on the specific recognition between one or more antibodies and an antigen, allowing for the detection and quantification of various antibodies in different types of samples (including serum, urine, saliva, environmental media, and more). Specifically, some rheumatoid arthritis biomarkers that have been developed for early diagnosis of RA include but are not limited to UH-RA 1, UH-RA 9, UH-RA 14, UH-RA 21, Rheumatoid Factor, 14-3-3 Eta Protein, PAD4, etc. Not only are RA biomarkers evolving, but so are their development solutions in the following approaches: * IVD Antibody Development * Antibody Pair Development * Antibody & Protein Conjugation * IVD Immunoassay Development https://www.creative-biolabs.com/drug-discovery/diagnostics/biomarker-and-antibody-development-for-rheumatoid-arthritis.htm
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Single-Cell CyTOF and Multi-Omics: Decoding the Complexity of Life One Cell at a Time In recent years, single-cell analysis has emerged as a powerful approach to dissect the biological heterogeneity that exists even within a seemingly uniform population of cells. Two cutting-edge technologies—single-cell mass cytometry (CyTOF) and single-cell multi-omics—are leading the way in helping researchers understand how cells function, interact, and change over time in development, disease, and therapy response. What Is Single-Cell CyTOF? Single-cell mass cytometry, or CyTOF, is a hybrid technology that combines the strengths of flow cytometry and mass spectrometry. Instead of using traditional fluorescent tags, CyTOF labels antibodies with heavy metal isotopes, allowing simultaneous measurement of over 40 markers per cell without spectral overlap. This means researchers can obtain highly multiplexed data from millions of cells—ideal for deep immune profiling, stem cell research, or monitoring disease progression. Because each antibody is conjugated to a unique metal tag, the readout is not affected by autofluorescence or signal spillover. This results in much clearer, more accurate data, especially when studying complex systems like the tumor microenvironment or autoimmune conditions where diverse cell types coexist in dynamic states. Going Beyond Proteins: Enter Single-Cell Multi-Omics While CyTOF is ideal for studying the protein landscape of a cell, single-cell multi-omics dives even deeper by integrating multiple layers of cellular information—such as DNA (genomics), RNA (transcriptomics), chromatin accessibility (epigenomics), and proteins (proteomics). By capturing two or more of these data types from the same individual cell, multi-omics techniques offer a more comprehensive understanding of gene regulation, lineage commitment, and cellular state. For instance, combining scRNA-seq (single-cell transcriptome sequencing) with ATAC-seq (assay for transposase-accessible chromatin) can not only reveal which genes are being expressed, but also explain why they are active, based on the accessibility of their promoter and enhancer regions. Such insight is essential when studying processes like cancer metastasis or immune exhaustion. Applications in Research and Medicine Single-cell CyTOF has already made a major impact in immunology. By profiling the expression of surface and intracellular proteins, scientists can classify immune cell subsets, monitor activation states, and track changes in response to infection or immunotherapy. For example, CyTOF has been widely used to study immune responses to COVID-19 vaccines and to characterize T-cell exhaustion in chronic viral infections and tumors. Multi-omics, on the other hand, is particularly powerful for studying developmental biology, neurodegeneration, and epigenetic disorders. In cancer research, it can help identify tumor subclones with distinct regulatory features that might respond differently to treatment. In regenerative medicine, multi-omics can reveal the transcriptional and epigenetic dynamics guiding stem cell differentiation. Integration for Deeper Insights The real magic happens when CyTOF and multi-omics approaches are integrated. By aligning high-dimensional protein expression data with transcriptomic and epigenetic profiles, researchers can build detailed models of cellular behavior and interactions. This is especially valuable in tumor biology, where immune cells, stromal cells, and malignant cells engage in complex cross-talk. For instance, using CyTOF to identify exhausted T-cell phenotypes and multi-omics to characterize their epigenetic signatures can help pinpoint targets for reactivation, guiding the development of next-generation immunotherapies. Final Thoughts As biology becomes increasingly data-rich, the need for high-resolution, multi-dimensional tools continues to grow. Single-cell CyTOF and multi-omics are not just technologies—they’re windows into the hidden lives of cells. Together, they are unlocking the secrets of development, immunity, and disease, one cell at a time. https://singlecell.creative-biolabs.com/single-cell-mass-cytometry-cytof.htm
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What is Emtricitabine/Tenofovir? Emtricitabine/Tenofovir is a combination antiviral medication used in the treatment of HIV (Human Immunodeficiency Virus) infection. It contains two active ingredients: Emtricitabine, a nucleoside reverse transcriptase inhibitor (NRTI), and Tenofovir, a reverse transcriptase inhibitor (NtRTI). This powerful combination works by inhibiting the reverse transcriptase enzyme, essential for the replication of HIV, thereby helping to control viral load and improve immune function. Available in tablet form, it is often prescribed as part of a comprehensive antiretroviral therapy regimen. Precautions to Take While Using Emtricitabine/Tenofovir to Treat HIV When using Emtricitabine/Tenofovir, taking certain precautions is essential to ensure the medication's effectiveness and minimize the risk of side effects. Here are some key precautions to consider: 1. Adherence to Therapy: Consistently take the medication as prescribed. Missing doses can lead to drug resistance and decreased effectiveness. 2. Kidney Function Monitoring: Regularly check kidney function through blood tests, especially if you have pre-existing kidney issues or are taking other medications that can affect kidney health. 3. Liver Function Monitoring: Monitor liver function before and during treatment, particularly if you have a history of liver disease or hepatitis B, as Tenofovir may cause liver complications. 4. Safe Sex Practices: Continue using safer sex practices, such as condoms, to reduce the risk of transmitting HIV or acquiring other sexually transmitted infections (STIs). 5. Inform Healthcare Providers: Notify your healthcare provider about all other medications you are taking, as Emtricitabine/Tenofovir can interact with specific drugs. 6. Screening for Hepatitis B: If you have a history of hepatitis B, ensure careful monitoring, as stopping treatment can lead to a worsening of the infection. 7. Hydration: Maintain proper hydration, especially if you experience gastrointestinal side effects like nausea or diarrhea, to prevent dehydration. 8. Bone Health: Discuss with your healthcare provider about monitoring bone density, especially if you have risk factors for osteoporosis, and consider calcium and vitamin D supplementation as needed. 9. Drug Interactions: Avoid taking over-the-counter medications or supplements without consulting your healthcare provider, as some substances may interact with the medication. 10. Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using this medication with your healthcare provider. 11. Regular Check-Ups: Schedule regular follow-up appointments with your healthcare provider to assess the effectiveness of the treatment and monitor for potential side effects. By following these precautions, you can help ensure a smoother treatment experience with Emtricitabine/Tenofovir. Always reach out to your healthcare provider with any concerns or questions regarding your medication. #hiv #aids #mtricitabinehivmedicine #Tenofovirhivmedicine #aidsmedicine #aidstreatment #aidscauses #aidstreatment #onlineharmacy #republicpharma #rxmedicine #republicrxr #mailorderpharmacy #onlineinternationalmailorderpharmacy
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Acupuncture Ease Symptoms COVID-19 Long Hauler If you're experiencing lingering symptoms after COVID-19, our acupuncture treatments for long haulers can help. At Ming Qi, we support post-viral recovery by improving energy, lung function, and overall immunity. Acupuncture and herbs work together to address fatigue, brain fog, shortness of breath, and more—helping your body heal naturally and fully. https://maps.app.goo.gl/BXq5ZGRsFUohsJ3P6
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