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E. coli Model for Protein Amplification Escherichia coli is a bacterium that most of us know first from recalls of foods like meat and lettuce. Although E. coli is a commensal (non-harmful) gut bacterium, the wrong circumstance and strain can make infection uncomfortable and dangerous. E. coli is gram negative, meaning it has a double-layered cell membrane that makes it more difficult to treat with antibiotics. Our homogenization equipment is regularly used to disrupt E. coli. In “Identification and Biosynthesis of pro-inflammatory sulfonolipids” authors Hou et al. use the NanoGenizer to break apart E. coli after using it for protein expression. Many other researchers have done the same (https://www.genizer.com/u_file/2206/file/6bffa6a456.pdf, https://www.genizer.com/u_file/2312/file/298f8a65e6.pdf , https://www.genizer.com/u_file/2312/file/3ca3c35d8a.pdf) What makes this common cause of diarrheal illnesses a welcome tool in so many research labs? First, we need to understand the research problem E. coli is being used to address in many labs. Researchers often need large amounts of proteins for a variety of purposes. One common example is for pharmaceutical production at a large scale. However, having to obtain that protein from its natural source can be time-consuming, resource intensive and complicated. Instead, researchers will often take the gene that encodes that protein and transform it into a bacterium. There, the bacteria will make that protein more quickly. However, not just any bacteria are suited for this purpose, and that’s what makes E. coli a laboratory star. Speed: E. coli can double as fast as every 20 minutes. Optimal conditions for quickly producing large quantities of protein. Density: E. coli can grow densely, reducing the amount of space required for protein production. Materials: E. coli can grow well on affordable and easily obtainable materials, making it accessible to researchers. Universality: The wide breadth of research done using E. coli as a model makes it easier to work with. Tractability: Tractability refers to the ease of editing a genome. E. coli is naturally genetically tractable and can pick up new genes and add them to itself. This eases the process of adjusting its genome for researchers. As a pathogen, this feature also helps E. coli evade antibiotics. So researchers, go forth and enjoy this model organism in the laboratory, if not always in your kitchen! Sources: https://www.ncbi.nlm.nih.gov/books/NBK564298/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4029002/ https://www.ncbi.nlm.nih.gov/books/NBK562895/ [more]
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The advantage of Genizer liposome extruders Genizer offers a comprehensive range of extruders suitable for researchers and manufacturers across all scales, from lab-scale HandExtruder and GJE-10mL/100mL models for small-scale research and development, to pilot-scale GJE-800mL/3000mL models for larger experiments and production runs, and the GOE-8L/25L extruder for large-scale commercial production. This means that regardless of the scale of the project, Genizer has an extruder that can meet the requirements. Genizer Liposome Extruders Genizer extruders can be easily connected to its own high-pressure homogenizers to create a powerful, integrated system. The intelligent control system of the homogenizers allows researchers and manufacturers to effortlessly set and adjust parameters, which enables precise control over critical factors such as temperature, pressure, and flow rate. By ensuring that the processes are efficient and accurate, the intelligent control system of the homogenizers results in consistent, high-quality liposomes. This integration also saves time, reduces the risk of contamination, and enables greater control over the final product. Multi Online Liposome Extruders System Genizer extruders are designed to meet strict pharmaceutical requirements and have been adopted by leading pharmaceutical companies worldwide, including Sanofi, Teva Pharma, GP Pharma and so on. These industry leaders have put Genizer's extruders to the test, and the results have been overwhelmingly positive. Genizer's extruders have received unanimous acclaim from these industry leaders for their reliability, precision, and efficiency and have become the go-to choice for pharmaceutical researchers and manufacturers worldwide. https://www.genizer.com/c/liposome-extruder_0365 If you are interested in our liposome extruders, you can visit our official website to get more information you want. [more]
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Scaling with Genizer: Homogenizers At Genizer, we want our equipment to be with you every step of the way! That’s why we make equipment that squeezes into an academic lab all the way up to manufacturing. Here’s the High-Pressure Homogenization equipment that can take you all the way to capacity. HandGenizer For a more portable solution to high-pressure homogenization, we have the HandGenizer. Well suited to long-term storage, the HandGenizer is great in an academic R&D context. Its’ distinctive manual option and compact size set the HandGenizer apart, though it is best suited to small, even solutions like nanoemulsions. NanoGenizer Next is the NanoGenizer. Our most popular model, the NanoGenizer fits easily in a benchtop with a length under 28 inches (70 cm). The Nanogenizer has a max flow of 100mL/min, and a max pressure of 45,000 psi. Ideal for R&D, laboratory, and small-scale production. The NanoGenizer is quiet and easy to use. It also comes in Dual and Quad options for additional capacity, and the NanoGenizer and all larger units have a MixGenizer option, for in-chamber mixing. UltraGenizer Our half-step up from the NanoGenizer is the UltraGenizer. The UltraGenizer comes with the unique ability to reach 60,000 psi! At a pressure of 30kpsi, it can reach 25L/Hr. It also has a higher runtime of 4-6 hours, giving a much higher processing capacity. PilotGenizer & ProdGenizer WillNano Finally, our WillNano ManuGenizer series is ideal for your manufacturing needs! The Willnano offers up to 4 pumps to reach your desired flow rate. At 30kpsi, these machines can reach up to 480L/hr. And if that still doesn’t meet your needs, there’s always more than one. We also offer many sanitary certifications and IQ/OQ documentation. With our scalable options, we know you can find the right size with Genizer! https://www.genizer.com/c/high-pressure-homogenizer_0360 You can visit our official website to get more information you want. [more]
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The NanoGenizer | A High-Pressure Homogenizer for Laboratory Settings The NanoGenizer is the most popular unit from Genizer. This high-pressure homogenizer is perfect for laboratory settings because of its compact and energy efficient design. The NanoGenizer is simple to use. It plugs into the wall and has a convenient touch screen with an auto-stop function. The body of the NanoGenizer serves as the engine to power the ceramic piston. The sample travels in through the inlet valve and out the outlet valve into the diamond interaction chamber (DIXC). The DIXC can be either Y-shaped or Z-shaped. In the Y-shaped interaction chamber, the sample separates into two streams. The streams turn at a 90° angle and collide with each other. Where the two streams collide, forces like high shear and cavitation homogenize the sample. While in the Y-shaped interaction chamber the sample collides with itself, in the Z-shaped chamber the sample collides with the wall of the chamber. In addition to the cooling function in the interaction chambers, Genizer offers a real-time cooling system, with the heat exchanger. This feature is useful for thermally unstable samples. Common applications for the NanoGenizer include but are not limited to nanoemulsions, cell disruption and deagglomeration. https://www.genizer.com/nanogenizer_p0039.html [more]
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3 Questions to Choose a Liposome Extruder 3 Questions to Ask While Looking for a Liposome Extrusion Option There are three questions to ask when you are choosing a liposome extrusion option. First, what pore size do you need? While a solo homogenizer reaches a liposome size of 20-30nm, any option with extrusion allows for more choice. Second, what power types do you have access to? The jacketed liposome extruders allow for gas power. An electric option is available if you go for a high-pressure homogenizer with or without an extruder. And manual options are available in the HandExtruder and HandGenizer. Third, what scale of sample do you need to process? Genizer makes extrusion options from 1 mL to manufacturing scale. There are advantages coming from the various options as well to help you make your choice! Reach out at la@genizer.com for more information. https://www.genizer.com/c/liposome-extruder_0365 [more]
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Dual-Light Nano Particle Sizer Laser Particle Sizer especially designed for submicron, nanoemulsions and nano particle size testing. Principle: Dynamic Light Scattering (DLS) https://www.genizer.com/dual-light-nano-particle-sizer_p0033.html You can visit our official website to get more information you want if you are interested in our products. [more]
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The difference of High-Pressure Homogenization vs. Sonication Homogenization is a crucial step in various industrial processes, including pharmaceuticals, food, and cosmetics. High-pressure homogenization (HPH) and sonication are two common homogenization techniques, but HPH offers several distinct advantages over sonication, especially when used with Genizer's high-pressure homogenizers. Genizer high pressure homoGenization Smaller Particle Sizes One of the most significant advantages of HPH over sonication is its ability to produce smaller particle sizes. HPH operates at much higher pressures and forces the sample through a narrow valve, resulting in a more intense and efficient homogenization process. This leads to smaller particle sizes, which can improve product quality, increase bioavailability, and enhance downstream processing steps such as filtration or extraction. Using NanoGenizer-30k experimental microjet high pressure homogenizer to homogenize the samples (before homogenization on the left and after homogenization on the right) Using NanoGenizer experimental microjet high pressure homogenizer to homogenize samples (Left: before homogenization, Right: after homogenization) Scalability and Energy Efficiency Another advantage of HPH over sonication is its scalability and energy efficiency. HPH systems can process larger volumes of material, making it a more efficient and cost-effective option for industrial-scale processing. Additionally, HPH is a more energy-efficient process than sonication, which can result in significant cost savings over time. Connectable basic fittings of NanoGenizer series microfluidic high pressure homogenizer Connectable basic fittings of NanoGenizer series microfluidic high pressure homogenizer Connectable basic fittings of Genizer series microfluidic high pressure homogenizer Connectable basic fittings of Genizer series microfluidic high pressure homogenizer NanoGenizer series experimental microfluidic high pressure homogenizer can be extended to connect multiple liposome extruders. NanoGenizer microfluidic high pressure homogenizer combines with online liposome extruders Gentler Processing Conditions Finally, HPH can be a gentler process than sonication, particularly when processing delicate samples like pharmaceuticals or biologics. Sonication generates heat and cavitation, which can damage sensitive compounds and reduce product quality. In contrast, HPH provides more precise control over processing conditions, allowing for a gentler and more consistent homogenization process. When it comes to high-pressure homogenization, Genizer's high-pressure homogenizers are among the most reliable and efficient options in the market. With advanced technology and user-friendly designs, Genizer's homogenizers offer precise control over processing parameters, enabling efficient and gentle processing of various samples. In conclusion, while sonication can be a useful tool for processing samples, HPH offers several advantages over sonication, including smaller particle sizes, scalability, energy efficiency, and gentler processing conditions. By using Genizer's high-pressure homogenizers, these advantages can be maximized, making HPH a preferred choice for industrial-scale processing in various fields. [more]
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Description: Genizer ultra high pressure transmitter has been designed for those applications with high pressures up to 60,000 psi (410Mpa). It’s ideal for monitoring the high pressure of homogenizers with the features of long-term stability, high accuracy and a sanitary stainless steel shell. Application: ≤ 60,000 psi high pressure homogenizer or other high pressure devices Performance: Sanitary for pharmaceutical applications Long-term stability High accuracy [more]
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Description: Sanitary Piston Pump to 2,000 bar with electric power and controllable flow. Application: Sanitary delivery of liquids Pressure pump in liposome extrusion Performance: Small (integrated design delivers the light weight and small dimensions) Smart (programming control systems confer diligent functions) Silent (noiseless performance with high-energy efficiency) Strong (more than 30 L/hr at 300 bar) CE compliant and RoHS compliant https://www.genizer.com/nanopump_p0024.html [more]
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HandPump (Sanitary Stainless) Description: Sanitary HandPump is used for the sanitary transfer of a small fluid sample under pressure. Application: Sanitary HandPump is used with Genizer online liposome extruders for testing preparation of liposomes and lipopolyplex for drug and gene delivery. Sanitary HandPump is hand-driven, portable and made with sanitary-grade materials. Performance: FDA-approved stainless steel Hand-driven https://www.genizer.com/handpump_p0025.html If you are interested in this product, you can visit our official website to get more informaiton you want of this handpump. [more]
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Nanogenizer: The Ultimate Solution for Nanoparticle Production Nanoparticles have become an important part of modern technology, playing a vital role in a wide range of fields, including medicine, energy, and electronics. However, the production of high-quality nanoparticles remains a challenge, making it difficult to take full advantage of their unique properties. To overcome this problem, Genizer has developed the Nanogenizer, a cutting-edge tool that makes nanoparticle production more efficient and accessible than ever before. The Nanogenizer is a compact and easy-to-use device that allows you to produce nanoparticles quickly and with a high degree of control. It uses a proprietary technology to create nanoparticles from a variety of materials, including metals, ceramics, and polymers. The resulting particles are highly uniform in size, shape, and composition, making them ideal for use in a wide range of applications. One of the key-benefits of the Nanogenizer is its high-yield production. It produces nanoparticles in large quantities, making it ideal for industrial-scale applications. Furthermore, it is designed to be scalable, so you can easily increase the size of your nanoparticle production as your needs grow. Another advantage of the Nanogenizer is its user-friendly design. It is simple to operate, and its instinct interface makes it easy to fine-tune your nanoparticle production to meet your specific needs. Whether you're an experienced scientist or a beginner, you'll be able to use the Nanogenizer with ease. The Nanogenizer is also incredibly versatile. It can be used to produce nanoparticles with a wide range of sizes, from just a few nanometers to several microns. This makes it suitable for a wide range of applications, including drug delivery, energy storage, and catalysis. In conclusion, the Nanogenizer is the ultimate solution for anyone looking to produce high-quality nanoparticles quickly and efficiently. With its high-yield production, user-friendly design, and versatility, it's the perfect tool for scientists, engineers, and researchers alike. Whether you're working in a laboratory or an industrial setting, the Nanogenizer is sure to revolutionize the way you produce nanoparticles. [more]
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Jacketed Liposome Extruder by Genizer: Solutions for Nano If you are working in pharmaceutical and gene development and delivery, there is a high chance you have at least heard of a liposome extruder. Genizer’s Jacketed Liposome Extruder is leading the industry in innovation and precision. Liposome extrusion is mainly done to formulate liposomes and achieve a uniform size distribution. Generating nanoscale liposome formulations, and preparing exosomes and artificial cell membranes are other processes that can be done with a liposome extruder. Diagram of Liposomes extruding through nano sized pores in polycarbonate membrane. There are many advantages to utilizing Genizer’s Jacketed Liposome Extruder. Firstly, Genizer’s Jacketed Liposome Extruders are unique in that they have a built in temperature control unit. Most of our jacketed liposome extruders are designed with jacketed barrels. With the ability to hook a cold water unit to its body, the jacketed liposome extruder can guarantee effective extrusion while working with samples that must maintain a certain temperature. This is particularly important when working with pharmaceuticals and genes because of their need to maintain bioavailability. Secondly, air-compression using a compressed nitrogen cylinder (or other gas chambers) is what drives the power behind jacketed liposome extruders. This ensures that the given pressure is enough to extrude samples through polycarbonate membranes. Diagram of different liposome extruder sizes ranging from lab scale to pilot scale. Lastly, there is a wide range of processing capacities allowing Genizer’s Jacketed Liposome Extruders to work in a wide range of applications and industries. The different models of extruders that differ in sample volume size starting with 2mL and going up to 3L in volume. This makes the extruders suitable for laboratory scale use all the way up to pilot scale use. With the addition of Genizer’s Online Liposome Extruders, formulation can even occur on a production and manufacturing scale. Genizer takes pride in their Jacketed Liposome Extruder’s abilities in various industry settings. With its temperature control, air-compression power, and wide range of applications, Genizer’s jacketed liposome extruder will produce nano-sized liposomes with impressive precision and accuracy. [more]
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The NanoGenizer Core Processing UnitNanoGenizer High-Pressure Homogenizer The NanoGenizer is a laboratory scale high-pressure homogenizer. There are two segments of the NanoGenizer, the power unit and the core processing unit. The core processing unit is where homogenization occurs. Before homogenization, the user places the sample in the inlet reservoir. Genizer offers a variety of options for your inlet reservoir. You may prefer a smaller or larger inlet reservoir depending upon the size of your sample. In addition to stainless steel, we offer plastic syringes and glass inlet reservoirs. Genizer also offers a variety of outlet reservoirs, where the sample goes after processing. You may prefer to use a jacketed glass cylinder, which you can connect to a laboratory chiller circulator for temperature control. Schematic of the NanoGenizer core processing unit,with the inlet reservoir, high-pressure pump, interaction chamber, heat exchanger and outlet reservoirFor small, valuable samples, the syringe option is best. You can hook a Luer hose up to the outlet valve and place the other end in the inlet reservoir to circulate your sample through the core processing unit multiple times. Most samples need 5-10 passes through the diamond interaction chamber (DIXC) to be fully homogenized. Alternatively, you can place the Luer hose into any outlet receptacle in your lab. The inlet and outlet valve ensures your sample travels the correct direction through the core processing unit. The inlet valve is a one-way valve that allows the sample to enter but not exit. The outlet valve is also a one-way valve and allows the sample to exit but not enter. The sample travels through the inlet valve, into the-high pressure cylinder, and out the outlet valve into the Diamond Interaction Chamber. The Diamond Interaction Chamber is where homogenization occurs. The chamber can be either Z-shaped or Y-shaped. In the Y-shaped diamond interaction chamber, the sample splits into two streams. Where the two streams collide, forces like high shear and cavitation homogenize the sample. In the z-type chamber, instead of the sample colliding with itself, it collides with the wall of the chamber. After homogenization, the particles are smaller and more uniform and liquids that would normally be immiscible can be mixed.Diagram of the path of liquid Z-shaped and Y-shaped interaction chambers Genizer's Diamond Interaction Chamber can come with a cooling option. Additionally, if you need more cooling properties, Genizer offers a real-time heat exchanger. This method of cooling is superior for thermally unstable samples. The NanoGenizer offers low minimum volume, low dead volume and temperature control options. Please click here for more information on the NanoGenizer. [more]
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Description: Genizer Online Liposome Extruders can be connected with a sanitary pump or high pressure homogenizer and are temperature controlled, from testing to manufacturing production of pharmaceutical liposomes for anti-cancer drugs. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Online Liposome Extruders are designed to generate homogeneous unilamellar liposomes and lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The Online Liposome Extruder offers virtually no dead volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals. Application: Liposome extrusion; Sterile filtration Performance: No dead volume Online extruder can control the temperature of extrusion related website: https://www.genizer.com/online-liposome-extruder_p0004.html If you are interested in our product, you can visit our official website to get more information you want. [more]
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Description: The HandExtruder is a manually powered extruder designed for the formulation of 0.25mL-2.0mL liposome and lipopolyplex with small samples. The sample is passed back through the membrane by being pushed back and forth between two syringes. Homogeneous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. The HandExtruder offers minimal dead-volume, is easy to clean and is suitable for sterilization. Temperature control is available Application: Liposome extrusion Performance: Low dead volume HandExtruder-1mL-RT can control the temperature of extrusion related website: https://www.genizer.com/liposome-handextruder_p0006.html If you are interested in our product, you can visit our official website to get more information you want. [more]
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