IgG molecules of the IgG1, IgG2, and IgG4 subclasses exhibit exceptionally long half-lives due to FcRn-mediated recycling. Half-lives of up to 4 weeks have been described for therapeutic antibodies. The binding site for FcRn resides in the Fc region is formed by the CH2 and CH3 domains. Learn more about Fc-Fusion Protein Development: https://half-life-extension.creative-biolabs.com/fc-fusion-protein-development.htm
 

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