Factors for iPSCs generation have been identified including Oct-3/4, Sox gene family, Klf family, Myc family, Nanog, and LIN28. Genes used for the induction can be effectively introduced and integrated into the genome of the somatic cells via a retroviral vector. However, retroviral delivery may increase the risk of virus-induced tumor formation. To overcome this issue, researchers have attempted to use the PiggyBac transposon system to effectively deliver the key transcription factors without leaving footprint mutations in the host cell genome. Learn more about IPS cell: https://www.creative-biolabs.com/stem-cell-therapy/ipsc.htm