Challenges and Controversies in Human Mesenchymal Stem Cell Therapy

The main therapeutic effects of mesenchymal stem cells are now attributed to the stimulation of endogenous repair processes in the injured tissues by secreted factors as well as immunomodulatory response.

The cellular heterogeneity of mesenchymal stem cells makes consistent conclusions on therapeutic potential seem difficult as results will depend on the different tissue origins as well as harvesting/ culture procedures.

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