kosheekaa's Updates (89)
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Mouse Kidney Epithelial Cells play a vital role in renal function and are widely used in biomedical research for studying kidney development, disease modeling, drug testing, and tissue regeneration. Explore how these cells, isolated through specialized protocols, aid in understanding renal physiology and pathologies like acute kidney injury and chronic kidney disease. Kosheeka provides high-quality, characterized primary kidney epithelial cells to support advanced renal research. -
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Discover the role of pancreatic beta cells in insulin production and diabetes therapy. Learn about their structure, function, pathophysiology, and regenerative strategies. Explore how Kosheeka supports cutting-edge diabetes research with high-quality pancreatic beta cells. https://trendburst.us/advancing-research-on-pancreatic-beta-cells-for-diabetes-treatment/ -
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Bone Osteoblasts: Drivers of Bone Development and Repair Osteoblasts are bone cells that synthesize the extracellular matrix (ECM) of bone and coordinate the bone modelling with other cells. The process is vital for bone development and fracture repair. Any imbalance in the process can cause severe disorders like osteoporosis. Several therapeutic options are currently under investigation. However, understanding osteoblast differentiation is crucial to develop an effective treatment... -
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MSCs have vast applications in the treatment of chronic disease, wound healing, and restoring tissue damage. Many clinical trials have been evaluating the safety and efficacy of these cells in therapy. These trials have been favoring the use of UCMSCs due to their easy availability and noninvasive extraction procedure. Several studies have shown positive outcomes with UCMSCs, suggesting the translation of UCMSC therapy into clinical settings in the future. Kosheeka provide premium quality... -
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Cardiovascular research has gained considerable attention due to high mortality by cardiac issues. Pigs are employed as animal models due to their similarity with the human heart. The primary swine or porcine cardiomyocytes can also serve as an in vitro research model. https://www.apsense.com/article/844196-swine-cardiomyocytes-in-cardiovascular-research.html [more]
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Pancreatic β-islet cells secrete insulin and are critical in the regulation of glucose homeostasis. Their dysfunction causes diabetes mellitus, turning these cells into the focal point of research. Exogenous insulin and insulin-regulating medications have been introduced as the first line of treatment. Kosheeka provides customized human and animal primary pancreatic β-islet cells to enhance your research and accelerate the drug development process. -
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Primary cell culture has influenced the research greatly. The cell survival, growth, and proliferation in culture require optimal medium. After years of research, numerous components of the medium have been identified, and several culture media has been formulated. The media has been modified based on specific cell culture needs. [more]
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Hematopoietic stem cells (HSCs) have a wide range of clinical applications. Their self-renewal and differentiation potential is being extensively studied. Manipulation of their genetic profile, altering their signaling pathways, and modifying their transplant procedure are being investigated. [more]
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Endothelial cells perform a myriad of functions. Alterations in their structure and function affect health and are related to many lethal diseases, which has piqued the interest of researchers. Scientists have elucidated various aspects of endothelial cell functions and their role in pathophysiological states. It has necessitated continuing the studies to further explore the potential of endothelial cells and generate new insights. -
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Preclinical studies on drug metabolism are often conducted on the liver. However, lungs provide valuable insights into the metabolism of inhaled drugs. The tissue models are difficult to procure and show considerable genetic variation. Primary pulmonary cells and cell lines are rendered inaccurate owing to the heterogeneous nature of lungs. In this case, subcellular fractions provide a better representation of lung metabolic enzymes.
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Primary cells have essentially replaced the need for animal experiments for numerous research studies owing to their genotypic and phenotypic resemblance to the tissue of origin. The cell culture follows simple steps for subculture and maintenance. The usual impediment of contamination can be avoided by taking necessary precautions. Thus, primary cells can be cultured without difficulties to boost scientific research.
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Cytotoxicity Assays are vital in evaluating the toxic effects of substances like drug candidates or biomaterials on living cells. These assays, including methods like Trypan Blue, MTT, and Alamar Blue, help measure cell viability and cytotoxicity in vitro. They are widely used in drug discovery, safety assessment, cancer research, and environmental studies, offering rapid, cost-effective, and animal-free testing solutions. Kosheeka provides high-quality cells optimized for reliable and... [more]
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Understanding Primary and Secondary Cells in Animal Cell Culture Primary cells and secondary cells are fundamental to animal cell culture. Primary cells are obtained directly from animal tissues retain the phenotypic traits of their tissue source. Have a restricted lifespan when cultured. On the hand secondary cells are obtained from cultures through subculturing and display modified characteristics compared to the original primary cells.
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Flow cytometry is a cutting-edge technology that analyzes physical and chemical properties of cells or particles as they pass through a laser beam in a fluid stream. It enables rapid, multi-parameter analysis using scattered and fluorescent light, making it invaluable in fields like immunology, molecular biology, and cancer research. With applications in cell sorting, apoptosis, signal transduction, and more, flow cytometry offers unparalleled insights into cellular function and behavior.... -
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C57 Mouse Liver S9 || Kosheeka At Kosheeka, our scientific team is working hard to optimize every test system, we are presenting to the world of ADME/DMPK/DDI studies, may it be subcellular fractions like S9, Cytosol or microsomes or primary cells like liver hepatocytes. The products, such as C57 Mouse Liver S9, C57 Mouse Liver Cytosol and C57 Mouse Liver Microsomes can serve as the best predictive system in drug development for the evaluation of liver and extrahepatic metabolism of drug... [more]
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