cataliesw's Updates (71)
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The blood-brain barrier (BBB) is unique because it has selective permeability (which also changes in some diseased conditions). The BBB is a complex system made up of a structurally distinct, continuous endothelial cell layer separating the blood from the extracellular fluid of the brain. The luminal plasma membrane of the endothelial cells is directed towards the blood, while the abluminal plasma membrane faces the brain. Learn more about in vitro bbb model:
Recent research has shown that PD-1 and PD-L1/PD-L2 pathway plays important roles in various cancers, including breast cancer, lung cancer, colorectal cancer, gastric cancer, bladder cancer, pancreatic cancer, prostate cancer, and DLBCL tumor. In this case, inhibitors targeting PD-1/PD-L1 have been reported for cancer therapy, and some of them are approved by FDA. Learn more:
Factors for iPSCs generation have been identified including Oct-3/4, Sox gene family, Klf family, Myc family, Nanog, and LIN28. Genes used for the induction can be effectively introduced and integrated into the genome of the somatic cells via a retroviral vector. However, retroviral delivery may increase the risk of virus-induced tumor formation. To overcome this issue, researchers have attempted to use the PiggyBac transposon system to effectively deliver the key transcription factors...
Creative Biolabs proudly offers clodronate liposomes. Clodronate liposomes are composed of clodronate molecules encapsulated in neutral liposomes, which are able to achieve the macrophage depletion after a single intravenous or intraperitoneal administration. Clodronate molecules encapsulated in small liposomes present superior activity, physical and chemical stability. Learn more about liposome clodronate:
Creative Biolabs has built a team of experienced scientists with facilities and processes designed specifically to provide the best strategy and protocols customized to bioburden determination services. We have accomplished many projects for detecting the number of viable microorganisms in a range of therapeutic areas. Learn more:
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), also known as CD152, ALPS5, CELIAC3, GRD4, GSE, or IDDM12, is a type of CD28 homolog molecule that plays an important role in regulating T cell activation. CTLA-4 is normally present in the vesicles of cells and is then transported to the immune synapse formed between T cells and antigen-presentation cells (APCs) and inhibits further activation of T cells by blocking T cell receptors and their signaling pathways. Learn more:
γδ T cells are promising candidates for developing anti-cancer immunotherapy. However, the lack of suitable expansion methods has hindered the wide application of γδ T cells in cellular immunotherapy. Creative Biolabs has organized a staff of excellent experts who have focused on the research of γδ T cell for many years. We provide optimal solutions for γδ T cell activation and expansion to support the development of γδ T cell-based...
Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells is a valuable method to produce patient-specific stem cells of any lineage without the use of embryonic materials. Various new strategies have been developed to improve the reprogramming technologies since the first report of iPS cells generation from murine fibroblasts using retroviral transduction of a defined set of transcription factors. Learn more about ipsc platform:
Calcium (Ca²⁺) is the essential element released from bone to bloodstream in humans. In neuroscience, calcium (Ca²⁺) plays fundamental and diversified roles. As ubiquitous second messenger in multiple signaling pathways, it has been proved that Ca²⁺ participates in multiple biological functions. The cytosolic Ca²⁺ concentration is regulated by the opening of the plasma membrane and subcellular Ca²⁺ sensitive channels and ultimately leads to the flexibility of...
Alzheimer's disease (AD), a common neurodegenerative brain disease, is mainly characterized by extracellular amyloid-beta (Aβ) plaque deposition and intracellular neurofibrillary tangles of phosphorylated tau protein, resulting in the loss of brain neurons. In recent years, Aβ peptide oligomerization has attracted much attention due to its effect on AD. In addition to various techniques, Creative Biolabs has developed various cell models such as AD in vitro models to facilitate...
Assays using gene arrays are powerful tools for the parallel, high throughput detection, and quantification of many nucleic acid sequences. The use of gene array-based assays has quickly expanded in various fields of clinical diagnostics. As an industry-leading biotechnology company, Creative Biolabs has established an advanced technology platform with excellent experts, thus we are capable of providing gene array development services to support the progress of disease diagnostics strategies....
As a leader and expert in the field of non-IgG therapeutic antibody development, Creative Biolabs is able to provide state-of-art technologies to meet any requirement of our customers. We have successfully completed a series of challenges in the past years. In particular, we have established advanced non-IgG antibodies (mainly IgA, IgM, and IgE) based therapeutic antibodies discovery platform which enables us to offer a series of high-quality therapeutic IgM antibody discovery services for...
Creative Biolabs offers the novel repetitive immunizations multiple sites (RIMMS) service for customers all over the world. Our professional scientists commit to locate the most appropriate method to achieve our clients’ research objectives and utilize our high quality services to make them a reality. Learn more about Repetitive Immunizations Multiple Sites (RIMMS) Immunization:
Complement factor H (CFH), a critical regulator of the complement activity, is a large glycoprotein encode by the CFH gene. In humans, five genes (CFHR1, CFHR2, CFHR3, CFHR4, and CFHR5) are found telomerically adjacent to the CFH gene and encode five different complement factor H related (CFHR) proteins. Learn more about CFHR2 Assay Kit:
In the nervous system, to maintain the efficiency of axons transmitting information over long distances in the form of electrical pulses, the myelin is required to wrap around the axon. Myelin is a lipid-rich specialized membrane generated by glial cells. In the central nervous system (CNS), myelin is generated from glial cells, which are also called oligodendrocytes. Learn more about oligodendrocyte development:Copyright 2019 © P-tweets Refunds
